Angiogenesis’ related genetic variants alter clinical features and prognosis of diffuse large B-cell lymphoma patients
نویسندگان
چکیده
OBJECTIVES: Single nucleotide variants (SNVs) in vascular endothelial growth factor A (VEGFA) and VEGFA receptor (KDR) genes confer different inherited abilities angiogenesis (AG) pathway. We aimed the present study to evaluate influence of six four KDR SNVs clinical features survival diffuse large B-cell lymphoma (DLBCL) patients. METHODS: One hundred sixty-eight DLBCL patients diagnosed between June 2009-September 2014 were enrolled study. Patients homogeneously treated with R-CHOP. Genotypes identified genomic DNA by real-time polymerase chain reaction. RESULTS: -634CC +936CT or TT genotypes at increased risk showing grade III / IV toxicities not achieving complete remission treatment, shorter event-free overall seen -1154GA AA genotype ATAGCC haplotype. CONCLUSION: Our data suggest that abnormalities AG’s gene modulate prognosis
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ژورنال
عنوان ژورنال: Tumor Biology
سال: 2021
ISSN: ['1423-0380', '1010-4283']
DOI: https://doi.org/10.3233/tub-211510